This has been shown to enhance cognition in older adults with memory impairments Reger et al. Increased cerebral uptake and oxidation of exogenous bHB improves ATP following traumatic brain injury in adult rat? Similar mechanisms are involved in the KD, during which long-chain fatty acids are metabolized in the liver and converted into KBs. Thus, their natural habituation is not associated with a decrease in exploratory behavior and this task can be tested daily to measure the extent to which animals are able to overcome anxiety regarding open spaces to retrieve a reward. Lefevre F, Aronson A. Hippocampus 12 : — Experience with the ketogenic diet in infants. This nucleotide is produced by the mitochondrial respiratory chain through oxidative phosphorylation, which is performed by five multienzyme complexes complexes I-V. Nutr Metab. Preferential utilization of ketone bodies for the synthesis of myelin cholesterol in vivo.
Importantly, these alterations are not uniform across the brain. Because higher cognitive functions require large—scale interactions across prefrontal cortical and hippocampal networks, selectively targeting an alteration within one region may not broadly restore function to improve cognition. One mechanism for decline that the PFC and HPC share, however, is a reduced ability to utilize glucose for energy metabolism. Thus, the current study used a ketogenic diet KD as a global metabolic strategy for improving brain function in young and aged rats. After 12 weeks, rats were trained to perform a spatial alternation task through an asymmetrical maze, in which one arm was closed and the other was open. Both young and aged KD-fed rats showed resilience against the anxiogenic open arm, training to alternation criterion performance faster than control animals. At the completion of behavioral testing, tissue punches were collected from the PFC for biochemical analysis. These data suggest that KDs could be optimal for enhancing large-scale network function that is critical for higher cognition.
Neuronal ketogenic diet brain scholarly article function
The KD by itself did transport and release. Lu M, et al. Metabolic control of vesicular glutamate not cause either cell loss. Dev Psychobiol 19 : 1- Muller-Schwartze et al. Although the mechanism by which.