Thank you for visiting nature. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. McClernon FJ et al. Obesity Silver Spring 15 : — Little is known about the effects of a low-carbohydrate, ketogenic diet LCKD on mood, hunger, energy levels, and mental and physical consequences of calorie restriction. McClernon and colleagues, therefore, evaluated these symptoms in a randomized, controlled trial that compared the LCKD with a low-fat, low-calorie diet LFD. The overweight volunteers were randomly allocated to receive either an LCKD or an LFD and were followed up for 6 months in 12 group meetings. Self-reported data from these participants were prospectively analyzed. Physical and psychological effects of these diets were compared in relation to seven domains—cognitive problems, fatigue, somatic symptoms, physical effects of hunger, insomnia, hunger, and stomach problems. Participants reported markedly improved symptoms with either diet, after adjustment for changed BMI.
Both treatment strategies improved certain risk factors, such as levels of cholesterol or glucose, and were well-tolerated. Notably, mice treated with pimozide had reduced circulating levels of glucose compared with control mice, suggesting that the increase in SCOT activity in obesity could be harmful. Authors Claire Greenhill View author publications. References Original article Al Batran, R. Please help by spinning off or relocating any relevant information, and removing excessive detail that may be against Wikipedia’s inclusion policy. High glucagon and low insulin correspond to times of low glucose availability such as fasting. Merck Veterinary Manual 9th ed. Subjects Circadian rhythms Epigenetics Homeostasis Nutrition. McClernon and colleagues, therefore, evaluated these symptoms in a randomized, controlled trial that compared the LCKD with a low-fat, low-calorie diet LFD. Finger-stick ketone meters allow instant testing of beta-hydroxybutyrate levels in the blood, similar to glucometers.
Thank you for visiting nature. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. Obesity induces alterations in carbohydrate, lipid and protein metabolism that can contribute to the development of type 2 diabetes mellitus T2DM. However, the effects of obesity on ketone metabolism are unclear. A study in Cell Metabolism now shows that obesity affects ketone body oxidation in skeletal muscle. Other tissues, such as skeletal muscle and cardiac tissue, can also oxidize ketone bodies. Ussher and colleagues investigated metabolism in a mouse model of diet-induced obesity. To investigate whether these obesity-associated changes were harmful or beneficial, the researchers undertook a virtual high-throughput screening programme to find potential antagonists of SCOT.